¶¶Òõ´«Ã½ÔÚÏß

We develop theoretical and computational models to fundamentally understand and predict how living matter remodels, grows, and adapts. Our work focuses on how mechanics and cell mechanosensing interact to create feedback loops that govern tissue development over time. By identifying the physical rules through which cells sense forces, reorganize their environment, and alter material properties, we aim to uncover the mechanisms that drive both healthy morphogenesis and pathological change.

We first explored these principles in simple organisms, such as phycomyces, where mechanical feedback plays a dominant role in organizing collective behavior. Building on these foundations, our current work targets the arterial wall, seeking to understand how mechanical cues and disrupted feedback pathways initiate and propagate vascular disease.