Integrative Physiology

Matthew Olm named a 2026 Boettcher Investigator

Rachel Sauer — Fri, 29 May 2026 17:10:55 +0000

Matthew Olm named a 2026 Boettcher Investigator Rachel Sauer Fri, 05/29/2026 - 11:10

Grant will support Olm’s research on how diet and lifestyle shape the infant gut microbiome and immune disease risk

Matthew Olm, a ��ý�� assistant professor of integrative physiology, has been named a member of the 2026 class of Boettcher Investigators.

Olm is one of eight early-career biomedical researchers at four leading Colorado academic and research institutions who each will receive a $250,000 grant through the Boettcher Foundation’s Webb-Waring Biomedical Research Awards Program to fund up to three years of independent scientific research.

The Webb-Waring Biomedical Research Awards provide critical early-career support and position recipients to compete for additional private, state and federal research funding while helping Colorado retain top scientific talent, according to the Boettcher Foundation.

Matthew Olm, a ��ý�� assistant professor of integrative physiology, has been named a member of the 2026 class of Boettcher Investigators.

“The awards are critical to Colorado’s future because of the investment in researchers at one of the most important stages of their careers, when bold ideas have the potential to create lasting impact,” said Katie Kramer, president and CEO of the Boettcher Foundation, in an announcement of the awards. “Colorado’s leadership in bioscience depends on ensuring that emerging researchers have the resources to pursue innovative work.”

The Boettcher grant will support Olm’s research on how diet and lifestyle shape the infant gut microbiome and immune disease risk.

“Immune diseases like asthma, allergies and type 1 diabetes have exploded in industrialized countries over the past 100 years, but they are still rare in non-industrialized settings,” Olm says. “The microbes that colonize infant guts in the first year of life appear to be critical for training the human immune system, and we hypothesize that something about modern life is disrupting this process. This funding gives us the ability to compare infant microbiomes across the globe using cutting-edge immunological and bioinformatics techniques. We hope this work will ultimately lead to the development of strategies to restore the infant microbiome to its historical state to prevent immune diseases before they start.”

Olm, who earned his bachelor’s degree at the University of Pittsburgh and his PhD at the University of California Berkeley, leads the Integrative Microbiome Research Laboratory, where he and his research colleagues study the human microbiome as “an entire ecosystem of microscopic organisms that live on our skin and inside our body. These microbes are integrated into our immune, digestive and nervous systems and are critical to our overall wellbeing.”

Olm and his colleagues aim to increase understanding of the human microbiome and its connections to physiology and to apply these findings to improve human health using cutting-edge, computer-based analysis and experimental techniques to study the microbiome.

The lab’s current research topics include:

From where do we get our microbiome? How do our microbes spread from person to person?
How does the infant gut microbiome influence the development of allergies and auto-immune disease?
How does our intestinal immune system control our gut microbiome? How do failures in this control lead to disease?

About the awards program

Since it began, the Webb-Waring Biomedical Research Awards Program has supported 121 Boettcher Investigators, including this year’s class, and awarded almost $29 million in grant funding. These researchers have gone on to secure more than $150 million in additional research funding from federal, state and private sources. The Boettcher Foundation’s Webb-Waring Biomedical Research Awards strengthen the state’s long-term competitiveness by helping emerging investigators accelerate breakthroughs for patients.

“Colorado’s future as a leading hub for health innovation depends on bold scientific thinking and sustained investment in emerging researchers,” said Elyse Blazevich, president and CEO of the Colorado BioScience Association, in an announcement of the awards. “The Boettcher Investigators are advancing high-impact discoveries across some of the most urgent challenges in human health while strengthening Colorado’s position as a center for biomedical research and innovation. These awards help accelerate breakthrough science, support exceptional talent, and reinforce the collaborative research environment that sets Colorado apart.”

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Grant will support Olm’s research on how diet and lifestyle shape the infant gut microbiome and immune disease risk.

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Scholar exercised science muscles in the gym

Rachel Sauer — Mon, 11 May 2026 16:36:25 +0000

Scholar exercised science muscles in the gym Rachel Sauer Mon, 05/11/2026 - 10:36

Cody DeBos

In new memoir, senior aging researcher Doug Seals chronicles the work of science when conditions aren’t ideal

Imagine a biomedical research laboratory. Chances are, visions of gleaming equipment, climate-controlled rooms, and the hum of precision instruments come to mind.

But what if that lab was really a century-old gymnasium plagued by electrical outages, noise and temperatures that swing with the seasons? Those are just some of the challenges Doug Seals faced while establishing one of the most productive aging research programs in the country.

Seals, a distinguished professor in the ��ý�� Department of Integrative Physiology, recently published a memoir chronicling more than four decades in biomedical research. In his own words, the book isn’t all about the science; it’s also about what it takes to succeed when conditions aren’t in your favor.

Doug Seals, a distinguished professor in the CU ��ý�� Department of Integrative Physiology, recently published a memoir chronicling more than four decades in biomedical research.

An unlikely scientist

Seals grew up in an under-educated family, his parents having only elementary school educations, and was the first in his extended family to attend college. As an undergraduate, he majored in education and business administration hoping to coach football.

A research career wasn’t on his radar.

“However, the program had a mandatory requirement to perform a research thesis, and I discovered that I really liked the research process,” Seals says.

That discovery set him on the path to where he is today.

Seals went on to earn his PhD at the University of Wisconsin-Madison, then completed his postdoctoral training at Washington University School of Medicine in St. Louis and at the University of Iowa before landing his first faculty position. He would eventually join CU ��ý��’s Department of Integrative Physiology (the Department of Kinesiology at the time) in 1992.

“Each stop along the journey provides a learning opportunity, and you take the new tool and add it to your toolbox,” he reflects.

Seals’ new memoir details the unique trajectory of his career and how little of it was the byproduct of elite circumstances.

“I had no conventional mentoring in graduate school (I did not belong to a ‘laboratory’), so I learned how to work on my own, independently,” he says, “which turned out to be helpful later.”

Bringing science to the gym

The title of Seals’ memoir, A Life of Science—In Gyms, isn’t a metaphor. For 30 years, Seals and a small group of colleagues ran NIH -funded research programs out of Carlson Gymnasium on the CU ��ý�� campus before moving out in 2020. The building, constructed in the 1920s, was never designed with biomedical research in mind.

Yet Seals and the other faculty found a way to make it work.

His idea for the book grew out of a period of reflection during the pandemic.

“As I was writing a series of personal commentaries during and post-pandemic, I began to think about penning a memoir of my unusual life of science in gyms,” he says.

He started by authoring a historical scientific article about the Carlson years, then realized the story was bigger than could be told in a journal piece.

“I decided to expand that story to include my earlier life and more details about the challenges I have overcome, which necessitated the longer narrative format of a memoir.”

The stories he chose to include during the writing process are, by his own account, the ones readers may find most compelling, particularly how Seals and his colleagues built a top academic research department at CU ��ý��.

“For example, I share how I obtained the funds to start the first research seminar series in the department . . . the challenges we faced performing NIH-funded research in an old gym designed for sport and how I eventually took matters into my own hands to upgrade our research facilities when the campus did not do so,” he says.

In his memoir, Doug Seals details the "challenges we faced performing NIH-funded research in an old gym designed for sport."

Despite the conditions, his lab secured continuous NIH funding, produced more than 350 peer-reviewed publications and trained more than 300 scientists across career stages from undergraduate to junior faculty.

Living long and living well

Woven through the memoir’s recap of institutional challenges is the science Seals has dedicated his career to. His lab’s central focus is the concept of extending “healthspan”—not just how long we live, but how long we live well.

“In biomedical aging research, ‘healthspan’ generally refers to the period of life that you retain good physical and cognitive function and are free of serious disease, whereas ‘lifespan’ is the entire period of life,” Seals explains.

He notes the two don’t always align. A long life shadowed by disability or chronic disease is a far different proposition than one that stays healthy into its final decades.

Seals has spent 40 years researching what tips the scale in favor of the latter.

Seals has clear advice for those seeking to improve their healthspan: “If I could recommend that people do only one thing, it would be to exercise regularly—to be physically active. No other strategy comes close to exerting the health benefits of regular exercise on physical and cognitive function and prevention of chronic diseases,” he says.

Diet, not smoking, and other factors matter.

“But the effects of regular exercise cannot be fully mimicked by any other lifestyle behavior or pill,” Seals adds.

In control of your fate

One of the more challenging aspects of writing the memoir, Seals admits, was choosing what to talk about.

“The most difficult challenge was trying to make the book compelling to both scientists and non-scientists. I wanted to provide a lot of ‘insider insight’ for the layperson, while not boring academics reading the story,” he says.

Through his careful curation of stories, the message he hopes to land is straightforward.

“The main message of the memoir is that you don’t need to come from the most educated family background, attend the most elite institutes of higher education, join the faculty of a top-ranked department or have the best research facilities to achieve and sustain success in your profession,” he says.

“You are the ‘master of your fate,’ not your environment. Your determination, creativity and resilience are much more important to the outcome than external factors,” Seals adds.

Seals lived this lesson before ever writing it down. Sitting atop the resume of a 41-year career built, improbably, in a gymnasium, he fears the perspective that has carried him through it all is going out of fashion.

“I worry that more recent generations may not fully understand this simple point of view,” he says.

The memoir is his attempt to make sure they do.

For anyone who has ever felt that the odds are stacked against them, Seals offers one last reminder: “Your personal agency is much more important in achieving your life goals than your immediate environment.”

A preview of A Life of Science—In Gyms! can be accessed at Physiology.org.

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In new memoir, CU ��ý�� senior aging researcher Doug Seals chronicles the work of science when conditions aren’t ideal.

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Top image: Carlson Gymnasium

How important is good sleep after a head injury?

Rachel Sauer — Tue, 14 Apr 2026 21:46:46 +0000

How important is good sleep after a head injury? Rachel Sauer Tue, 04/14/2026 - 15:46

Blake Puscher

Research suggests that disrupted or fragmented sleep after a traumatic brain injury not only interferes with the healing process but also has long-term consequences for brain health

Millions of Americans, and far more people worldwide, report sustaining a traumatic brain injury (TBI) each year. While detection and treatment of TBI have improved over time, this has resulted in new challenges, because survivors may face additional health problems over time as a consequence of their injuries. These problems can include cognitive impairment and even neurodegeneration, including Alzheimer’s. Considering this, there is an increased interest in what factors determine how well TBI patients recover.

Rachel Rowe, an assistant professor of integrative physiology at the ��ý��, has investigated this question, along with a number of researchers from The Ohio State University and the University of Arizona College of Medicine, in a recent study linking low-quality sleep following traumatic brain injury to cognitive impairment, persistent inflammation and delayed healing.

Rachel Rowe, a CU ��ý�� assistant professor of integrative physiology, collaborated on research linking low-quality sleep following traumatic brain injury to cognitive impairment, persistent inflammation and delayed healing.

The study used mice as a controlled experimental model to examine how sleep fragmentation interacts with traumatic brain injury, following the National Institutes of Health Guidelines for the Care and Use of Laboratory Mice, and with approval from Ohio State’s Institutional Animal Care and Use Committee.

Sleep fragmentation, inflammation and microglia

The study did not look at total sleep loss, but instead at sleep fragmentation, which happens when sleep is repeatedly interrupted. Even brief awakenings can prevent the brain from staying asleep long enough to reach the deeper, more restorative stages of sleep. When sleep is broken up many times throughout the night, people may spend less time in these restorative phases, which are important for physical recovery and brain health. Unfortunately, fragmented sleep is common and can be caused by everyday factors such as noise, hospital monitoring, discomfort or changes in temperature.

“For instance,” Rowe says, if someone is in the hospital for a moderate brain injury, “then there are a lot of people coming in, they’re checking monitors, they’re doing activities that could disrupt the sleep of a person.”

Stress can also affect the quality of sleep. “We have got a lot of things in our society that disrupt our sleep,” Rowe says, and people do not always prioritize restful sleep after an injury. These types of disturbances may influence recovery following brain injury.

One reason for this is inflammation, which is a potential determiner of the long-term results of TBI, particularly whether it will result in neurodegeneration. Brain inflammation is an innate immune response initiated by cells called microglia. Similar to a fever, inflammation does not directly target infections, damaged cells or other threats but rather makes the body inhospitable to them. This allows for a quick response to potentially life-threatening challenges, but it can also damage the body if it goes on for too long. One reason that could happen is if the microglia are primed.

When the brain faces some kind of stress, like from an injury or from sleep fragmentation, the microglia become primed, meaning they respond more strongly to subsequent challenges.

“There is some memory in your immune system,” Rowe explains. “That is how vaccinations work. In the case of a brain injury, if it is mixed with sleep fragmentation, it is what we call a two-hit model.” When both stressors come in short succession, “that can change what the microglia are doing,” potentially resulting in a heightened or prolonged inflammatory response in the brain.

Preparation and testing

The mice were split into four groups. Some mice were given traumatic brain injuries using lateral fluid percussion injury, a well-established experimental model used to study TBI in rodents. Other mice were not given traumatic brain injuries, but were put through the same preparation process, so the only difference was that they went uninjured.

Additionally, some mice experienced sleep fragmentation while others did not. Ultimately, the groups were traumatic brain injury (TBI) with sleep fragmentation (SF), TBI without SF, uninjured with SF, and uninjured without SF. This design allowed the researchers to examine the independent and combined effects of injury and sleep disruption.

Sleep fragmentation was achieved through disturbances that happened automatically every two minutes for five hours per day during the early light phase, when mice normally obtain most of their sleep. All mice experienced a simulated light/dark cycle where each half lasted 12 hours. Sleep fragmentation began an hour before the end of the dark period and ended four hours after the beginning of the light period.

“Mice are nocturnal,” Rowe says, “so the study was designed to fragment their sleep right at the beginning of the light period, which is when mice normally get most of their sleep. In many ways, it’s similar to repeatedly waking a person just as they are trying to fall asleep at night.”

The mice’s sleep, including both when they were asleep and how long they stayed asleep, was measured using specialized piezoelectric sensors. This technology has been popularized recently through its use to generate electricity from people walking on piezoelectric tiles in places with heavy foot traffic in Japan. The sensors from the study work according to the same principle, transforming pressure from the mice’s movements into electrical signals.

“Sleep is a time when the brain can heal, and if that is disrupted, the healing process can be disrupted too,” says CU ��ý�� scientist Rachel Rowe. (Photo: Mart Production/Pexels)

“When a mouse drops into sleep,” Rowe explains, “their breathing gets really rhythmic at 3 hertz.” The frequency of pressure created by that breathing was distinguished from the way mice breathe when they are resting using an algorithm.

Sleep fragmentation continued for 14 days following injury. After this period, mice were allowed to recover with normal sleep conditions, and researchers evaluated behavioral and molecular outcomes. One of the behavioral assessments used was the Morris Water Maze, a common test of spatial learning and memory in rodents. In this task, mice learn to locate a hidden platform in a pool using spatial cues in the environment. Their ability to remember and efficiently navigate to the platform reflects spatial memory performance.

How good sleep improves outcomes

When tested in the Morris water maze, mice with TBIs who also experienced sleep fragmentation used random search strategies, indicating that they did not learn the cues or that they did not remember them. This means that sleep fragmentation after this type of injury could impair spatial learning and memory.

“If there are cognitive deficits, then the mouse is looking at those cues, but it does not know which one is near the platform. It is just searching randomly because it does not know what it is supposed to be doing,” Rowe says.

Researchers also looked at what was happening inside the brains of the mice. They found that when brain injury was combined with disrupted sleep, the brain showed stronger signs of inflammation and less activity in the genes involved in repairing and rebuilding connections between brain cells. These connections, called synapses, allow brain cells to communicate with each other and are important for recovery after injury. In other words, poor sleep after a brain injury appeared to increase inflammation while slowing some of the brain’s natural repair processes. In contrast, mice that had a brain injury but were able to sleep normally showed stronger signs of these repair pathways being activated.

There were 14 days for the mice to recover from sleep fragmentation before these results were measured, and they had 30 days to recover from the injury itself. This indicates that the consequences were long-term or chronic.

“When we are looking at rodents,” Rowe says, “their lifespan is much shorter than humans’.” In mouse studies, researchers often consider about one month after injury to represent a chronic time point. “So, when we see effects at 30 days in a mouse, it suggests that the biological changes are lasting well beyond the immediate injury period.”

While animal models cannot directly predict human timelines, these findings indicate that sleep disruption shortly after a brain injury may have long-term consequences for recovery.

“The chronic time period is when you start thinking about longer-term consequences of brain injury,” Rowe says. If inflammation persists beyond the initial injury phase, even at lower levels, it can create an environment that interferes with normal brain recovery. “You can start to see sustained inflammatory signaling, stress on neurons and changes that may contribute to neurodegenerative diseases over time.”

In summary, when combined with sleep fragmentation, TBI can weaken spatial learning and memory, cause persistent inflammation and prevent proper healing. If this inflammation continues for long enough, it can cause serious, permanent damage to the brain, potentially resulting in long-term neurological consequences or pathology associated with neurodegenerative diseases like Alzheimer’s.

“Sleep is a time when the brain can heal,” Rowe says, “and if that is disrupted, the healing process can be disrupted too.” Ultimately, the study shows that “if you are not protecting sleep after a concussion or brain injury, there are some long-term consequences through inflammatory pathways, and that can delay your healing process.”

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Research suggests that disrupted or fragmented sleep after a traumatic brain injury not only interferes with the healing process but also has long-term consequences for brain health.

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Menstrual pads and tampons can contain toxic substances

Rachel Sauer — Fri, 20 Feb 2026 18:29:13 +0000

Menstrual pads and tampons can contain toxic substances Rachel Sauer Fri, 02/20/2026 - 11:29

Jenni Shearston

CU ��ý�� scholar highlights what to know about this emerging health issue

About half of the global population menstruates at some point in their lives. Disposable products, such as tampons and pads, are some of the most popular products used around the globe to manage menstrual flow.

Unfortunately, studies have shown that many personal care products, including shampoo, lotion, nail polish and menstrual products, contain hazardous chemicals. Items used in or near the vagina are of particular concern because they are in contact with vaginal mucous membranes—the moist tissue lining the inside of the vagina that secretes mucus. These tissues can absorb some chemicals very efficiently.

People use menstrual products 24 hours a day for multiple days monthly, over the course of many years. Tampons, which are used internally, are surrounded by the permeable vaginal mucous membrane for up to eight hours at a time.

CU ��ý�� scientist Jenni Shearston is principal investigator in the Chemicals, Environment, Equity, Public Health, and Periods (CEEP.) Lab.

I am an environmental epidemiologist, and I study chemical exposure, its sources and its health effects. As a person who menstruates, I also must make my own decisions around menstrual products and manage the challenge of finding accurate information about women’s health risks, which receive less research attention and funding than men’s health.

In 2024, I co-authored the first paper that detected metals in tampons, including toxic metals like lead and arsenic. My colleagues and I also wrote a review paper that surveyed the scientific literature and found about two dozen studies measuring chemicals in menstrual products.

The various chemicals that these studies detected were typically at concentrations low enough to make their health impact unclear. However, they included chemicals known to disrupt the endocrine system, which makes and controls hormones that are essential for bodies to function.

How contaminants get into menstrual products

The first modern tampon in the U.S. was patented in 1931. Nearly a century later, tampons still are made primarily from cotton, rayon or a blend of the two.

Chemicals may get into tampons and other menstrual products in a number of ways. Some chemicals, like heavy metals, are present in soil, either naturally or due to pollution, and may be absorbed by cotton plants.

Other chemicals, such as zinc, may be intentionally added to menstrual products to prevent the growth of harmful bacteria. Still others, such as phthalates—synthetic chemicals used to manufacture plastics—may leach into menstrual products from plastic packaging or be added as part of a fragrance.

Research suggests that these chemicals are present in a large proportion of menstrual products – we found lead present in all 30 tampons we tested. What we don’t yet know is if these chemicals can get into people’s bodies in a high enough concentration to cause health effects in either the reproductive system or elsewhere in the body.

Limited federal regulations

The U.S. Food and Drug Administration regulates tampons, menstrual cups and scented menstrual pads as Class II medical devices, which carry moderate to medium risk. Unscented menstrual pads are Class I medical devices, which are considered low-risk. These categories are based on the risk the device may present to a consumer who uses it in the intended way.

FDA guidance for Class II devices offers only a few general guidelines with respect to chemicals. For menstrual tampons and pads, it recommends—but does not require—that products should not contain two specific dioxin products or “any pesticide and herbicide residues.” Dioxins are a chemical by-product of the bleaching process to whiten cotton, and they are associated with cancer and endocrine disruption. Using non-chlorine bleaching methods can reduce dioxin formation.

The most stringent regulation of tampons in the U.S. occurred after an illness called toxic shock syndrome became a public concern in the 1970s and 1980s. Menstrual toxic shock syndrome occurs when the bacteria Staphlococcus aureus grows in the vagina on inserted menstrual products and releases a toxin called TSST-1. This substance can be absorbed through the vaginal mucosa and cause a variety of symptoms, including fever, high blood pressure, shock and even death.

During this epidemic, in which at least 52 cases were recorded and seven people died over a period of eight months, tampons were associated with the syndrome—especially a highly absorbent tampon called Rely, which was pulled from the market.

The U.S. Food and Drug Administration regulates tampons, menstrual cups and scented menstrual pads as Class II medical devices, which carry moderate to medium risk. (Photo: iStock)

In response, the FDA created a task force that recommended standardizing the tampon absorbencies and advised consumers to use the lowest absorbency for their flow. This is why tampons in the U.S. now come in a range of absorbencies, from light through regular to super and ultra, so that users can choose the level they need while minimizing risk of toxic shock.

Living in a ‘soup of chemicals’

Just because a chemical is present in a menstrual product doesn’t mean it can get into the body. However, chemicals like lead and arsenic are known threats to human health. So it’s important to study whether harmful chemicals present in menstrual products could contribute to health problems.

Humans in the modern world live in what expert toxicologist Linda Birnbaum, former director of the National Institute of Environmental Health Sciences, calls a “soup of chemicals.” Simply being present on Earth means being exposed to many chemicals, at different concentrations, all at once. This makes it difficult to unravel the relationship between a single chemical exposure and health.

Nonetheless, science has shown that chemical exposure from at least one menstrual product—vaginal douches—does affect health. Vaginal douching is the process of washing or cleaning the inside of the vagina with water or other fluids.

The American College of Obstetricians and Gynecologists recommends avoiding this process, which can harm healthy bacteria in the vagina, increasing the risk of vaginal infections and other diseases.

In addition, a 2015 study found that women who use vaginal douches have higher concentrations of a chemical called monoethyl phthalate in their urine. Exposure to this substance is associated with reproductive health problems, such as reduced fertility and increased pregnancy risk.

Can these chemicals be absorbed?

Scientists are working now to determine what concentrations of metals and other chemicals can leach out of tampons and other menstrual products. One 2025 study estimated that volatile organic compounds, a group of chemicals that vaporize quickly, can be absorbed through the vaginal mucosa. Volatile organic compounds may be added to menstrual products as part of fragrances, adhesives or other product components.

My team and I are now shifting our focus to the relationship between menstrual product use, various chemicals, and menstrual pain and bleeding severity. We want to see whether some chemicals will be elevated in menstrual blood, whether these chemical levels are higher in people who use tampons, and whether the chemicals are associated with greater menstrual pain and bleeding.

States are starting to act on this issue. For example, in 2024, Vermont became the first U.S. state to ban multiple chemicals from disposable menstrual products. California bans PFAS, a widely used group of highly persistent chemicals, from menstrual products. New York adopted a law in December 2025 barring multiple toxic chemicals from menstrual products.

California also enacted a law in October 2025 that requires manufacturers of disposable tampons and pads to measure concentrations of arsenic, cadmium, lead and zinc in their products, and to share those measurements with the state, which can publish them. More information like this will help support informed choices for millions of consumers who rely on menstrual products every month.

Jenni Shearston is an assistant professor in the Department of Integrative Physiology.

This article is republished from The Conversation under a Creative Commons license. Read the original article

CU ��ý�� scholar highlights what to know about this emerging health issue.

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Murder and the microbiome

Rachel Sauer — Thu, 11 Dec 2025 14:40:00 +0000

Murder and the microbiome Rachel Sauer Thu, 12/11/2025 - 07:40

Daniel Long

A paper co-authored by CU ��ý�� researcher Christopher Lowry draws upon the infamous ‘Twinkie defense’ to explore the relationship between ultraprocessed foods and human behavior

On November 27, 1978, in the heart of San Francisco, former City Supervisor Dan White climbed through a window into City Hall, pulled out a gun and fatally shot Mayor George Moscone and City Supervisor Harvey Milk. He then turned himself in to the police, saying, “Why do we do things . . . I don’t know . . . I just shot [Moscone], I don’t know.”

In the trial that followed, People v. White, which ran from May 1-21, 1979, White’s defense argued not that White was innocent—he’d confessed, after all—but that, when he committed the murders, he’d been suffering from “diminished capacity” and was therefore incapable of premeditation, a key requirement of first-degree murder charges.

One revealing piece of evidence, the defense claimed, was White’s diet. For days leading up to the shootings, White had been gorging himself on junk food, an abnormal behavior for the typically health-conscious former police officer, firefighter and Army veteran.

CU ��ý�� scientist Christopher Lowry and his research colleagues suggest a link between ultraprocessed foods and human behavior.

It was a risky legal tack—journalists at the time mockingly dubbed it the “Twinkie defense”—but it worked. White was charged with voluntary manslaughter, a lesser charge than first-degree murder, and received a prison sentence of just under eight years, of which he ended up serving only five.

A fierce backlash followed the ruling. Many took to the streets to express their outrage, most notably with the White Night Riots, while others took to the media.

“There is no question that a travesty of justice occurred in the trial of Dan White,” wrote psychiatrist Thomas Szasz. “In the trial of Dan White, the defense, aided and abetted by the prosecution, had the power to hand the case over to the psychiatrists, and the psychiatrists had the power to redefine a political crime as an ordinary crime, and an ordinary crime as a psychiatric problem.”

Yet in a paper published in the journal NeuroSci, ��ý�� Professor of Integrative Physiology Christopher Lowry, along with several co-authors, suggests that the White case might have been ahead of its time in assuming a link between ultraprocessed foods and human behavior.

Gut reactions

It’s unsurprising that so many people found White’s claim of diminished capacity less than persuasive, says Lowry. In 1979, the scientific community hadn’t yet recognized the microbiome, or the commonwealth of bacteria occupying the human gut. The connection between it, one’s diet and one’s behavior therefore seemed flimsy.

“We didn't know that there was a microbiome, and that the microbiome impacts behavior,” Lowry explains. “[White’s defense team] was just basing their conclusions on observations that these types of foods, these ultraprocessed foods, could affect people’s behavior in negative ways. So, it was kind of a crude assessment of this association between what you eat and behavioral outcomes.”

But for the past several decades, scientific research in a field referred to as psychoneuroimmunology, much of it pioneered by Steven F. Maier and Linda R. Watkins of CU ��ý��’s Maier Watkins Laboratory, has established a clear relationship between microbes (or their components), the brain and behavior.

A crucial explanatory ingredient in this relationship, says Lowry, is inflammation, or the body’s immune response to what it deems threats.

“There’s a through-line between diet impacting the microbiome and the permeability of the gut barrier, which allows bacteria and bacterial products to get into the body, which can drive systemic inflammation. Systemic inflammation drives neuroinflammation in the brain, and neuroinflammation in the brain alters brain and behavior.”

“Given the growing evidence that ultraprocessed foods lead to multiple negative health outcomes, I think the goal is to shift away, to the extent possible, from ultraprocessed foods toward less processed food,” says CU ��ý�� researcher Christopher Lowry. (Photo: iStock)

The takeaway, Lowry explains, is that some foods—namely ultraprocessed foods—can negatively affect the microbiome and thus increase risk factors for violent or rash behavior. “It’s clear that inflammation does impact aggressive behavior, does impact impulsivity.” It’s so clear, in fact, that the negative health outcomes of ultraprocessed foods are now at the forefront of public health policy, and San Francisco is suing makers of ultraprocessed foods for creating products that have saddled governments with public health costs.

Yet the news isn’t all bad, Lowry says. Just as ultraprocessed foods can lead to negative mental health outcomes, less-processed foods can lead to positive mental health outcomes.

“What other researchers have found is that, regardless of whether you look at people without a diagnosis of depression or anxiety, or you look at clinical populations—people that have a diagnosis of anxiety disorder or mood disorder—in either case, you can simply change the diet of these individuals [by reducing their intake of ultraprocessed foods] and improve their anxiety and depression symptoms.”

Food or foodlike substances?

Moving away from ultraprocessed foods would mean big changes for many Americans, says Lowry, who points out that more than 50% of the foods purchased in U.S. grocery stores are ultraprocessed.

But what counts as ultraprocessed anyway? Don’t most foods go through some degree of processing before ending up on eaters’ plates?

One useful resource, says Lowry, is the four-level NOVA system developed by Carlos Augusto Monteiro and a team of researchers at the University of São Paulo in Brazil in 2009.

“Level 1 is unprocessed. This would be if you pulled the carrot out of the ground and ate it,” says Lowry. “Level 2 involves more processing,” but it’s processing “that we can do in our kitchen. So, you might take a carrot and combine it with some celery and spices and make a stir-fry that you put on rice.”

Level 3 involves processing that people generally can’t perform in their kitchens. “For example, there’s very few of us that can take salmon and make canned salmon. It’s food—it’s salmon—but it’s been processed in a way with very high heat and pressure to make it sterile so that it has a prolonged shelf life.”

Level 4, on the other hand, is another thing entirely, different from the other three levels not just in degree but in kind.

“Level 4 is not food,” says Lowry. “Level 4 is chemicals that have been put together in a way that makes them highly palatable.” In the words of Michael Pollan, Level 4 processing produces not food but “edible foodlike substances.”

To avoid inflammation—and its attendant behavioral risk factors—Lowry suggests eaters opt for the first three levels and do their best to steer clear of the fourth.

Just as ultraprocessed foods can lead to negative mental health outcomes, less-processed foods can lead to positive mental health outcomes, says CU ��ý�� scholar Christopher Lowry. (Photo: Jacopo Maiarelli/Unsplash)

“Given the growing evidence that ultraprocessed foods lead to multiple negative health outcomes, I think the goal is to shift away, to the extent possible, from ultraprocessed foods toward less processed food,” he says. “The diets that have benefit are rich in fresh fruits, vegetables, nuts, seeds, healthy fats like olive oil and occasionally fish.”

Free will on trial

In their paper, Lowry and his co-authors raise questions about the role of free will in criminal law. Specifically, how much responsibility does a person bear for a crime they committed while under the influence of diminished capacity?

A few non-food-related examples bring this question into stark relief.

Shane Tamura, who in July shot four people in a Manhattan office building before killing himself, was revealed in an autopsy to have had low-level chronic traumatic encephalopathy (CTE), a disease often associated with contact sports like football and boxing. “[S]tudy my brain please,” he said in his alleged suicide note. “I’m sorry.”

And Charles Whitman, the “Texas Tower Sniper” who in 1966 killed his wife, his mother and 11 people on the University of Texas at Austin campus, likewise requested that he undergo an autopsy following his crimes.

“[L]ately (I can’t recall when it started) I have been a victim of many unusual and irrational thoughts,” the Eagle Scout, scoutmaster and Marine veteran wrote in his confession the night before his crimes. “After my death I wish that an autopsy would be performed on me to see if there is any visible physical disorder. I have had some tremendous headaches in the past and have consumed two large bottles of Excedrin in the past three months.”

During the autopsy, medical examiners discovered a nickel-sized tumor pressing up against Whitman’s amygdala. Since the 1800s, researchers have known that damage to the amygdala can cause emotional and social disturbances.

Whether Tamura’s and Whitman’s brain pathologies directly caused their crimes is unknown and impossible to prove, but if their writings are any indication, they didn’t seem fully committed to perpetrating those crimes. And yet perpetrate them they did. What if something similar happened with Dan White? What if what people eat alters their sense of what they choose to do—their free will?

Of course, some philosophers and scientists don’t believe free will exists at all, perhaps the most popular among them being the neuroscientist Robert Sapolsky, author of Determined: A Science of Life without Free Will.

“When most people think they’re discerning free will, what they mean is somebody intended to do what they did: Something has just happened; somebody pulled the trigger. They understood the consequences and knew that alternative behaviors were available,” Sapolsky says in a New York Times interview.

“But that doesn’t remotely begin to touch it, because you’ve got to ask: Where did that intent come from? That’s what happened a minute before, in the years before, and everything in between.”

For his part, Lowry expresses less certainty than Sapolsky, but he nevertheless believes the issue of free will as it relates to ultraprocessed foods, the brain and human behavior is an important one to consider.

“If you’re born in an inner city with low socioeconomic status, you have very limited access to fresh foods—vegetables, nuts, seeds, healthy foods—and instead you’re raised on ultraprocessed foods, which are very cheap, do you ultimately have free will? Do you have the mental foundation to make decisions based on free will? Or is your free will somehow compromised by these conditions, which, at one level, are imposed by societal factors?

“This is a philosophical question,” Lowry adds. “I don’t claim to have the answer.”

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A paper co-authored by CU ��ý�� researcher Christopher Lowry draws upon the infamous ‘Twinkie defense’ to explore the relationship between ultraprocessed foods and human behavior.

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Top photo: Thayne Tuason/Wikimedia Commons

From Huffy to high tech, it's been a wild ride

Rachel Sauer — Fri, 05 Sep 2025 19:29:05 +0000

From Huffy to high tech, it's been a wild ride Rachel Sauer Fri, 09/05/2025 - 13:29

Rachel Sauer

For CU ��ý�� alumnus Todd Carver, what he learned in the lab as a student inspired industry-rocking innovation in developing digital bike-fitting technology

For a long time, one of the unspoken truths of cycling was that if you ride hard and long enough, it’s going to hurt: foot or hand numbness, back pain, shoulder pain, the list is intimidating.

Every rider feels it differently. For Todd Carver (IntPhys’00, MIntPhys’02), “my lower back is the problem. I struggled with my position but finally got to the point where I could ride pain-free as I understood the human body more and was actually able to make changes to my position on the bike.

“Plus, the bike’s adjustable, right, so you can move the seat, you can adjust your touchpoints to the bike, your hands, butt and feet can all be adjusted. And if you don’t adjust those and just plop yourself on the bike, there’s a chance you’re not going to perform well and you’re going to get injured.”

CU ��ý�� alumnus Todd Carver (IntPhys’00, MIntPhys’02) co-founded Retül, a bike fitting and product matching technology now used by professional cycling teams, performance centers, rehabilitation centers and bicycle retailers worldwide.

While working with Bill Byrnes and Rodger Kram, associate professors emeritus in the ��ý�� Department of Integrative Physiology, in the Applied Exercise Science Laboratory during his graduate studies, Carver began wondering if competitive cycling—or even long-distance recreational cycling—needed to end in pain.

“The big thing the cycling world was missing was information about the rider—the human aspect,” Carver explains. “How should riders fit on a bike? How do you position a rider to be powerful, efficient and perform well? All the things I was learning in my academic career under Bill Byrnes and Rodger Kram—the focus of my research—was in predicting cycling performance, who’s going to perform well and who’s not.”

The problem was, there just weren’t that many tools to assess a rider’s position on their bike and give them a three-dimensional, dynamic bike fit. So, Carver and two colleagues developed one: Retül, a bike fitting and product matching technology now used by professional cycling teams, performance centers, rehabilitation centers and bicycle retailers worldwide.

Retül wrought such a change in the cycling world that Specialized acquired it in 2012. Now, as head of human performance for Specialized, Carver continues to innovate at the vanguard of cycling fit and performance.

“Riders just want to be pain free,” Carver says. “And even if they don’t care about being fast, they don’t want to push on the pedal and not go or push on the pedal and it hurts.”

Bike = freedom

Carver discovered young that pushing on a bike pedal is bliss and freedom in equal measure. “My first bike was a Huffy, and it was frickin’ rad,” he recalls. “As a kid, I realized that on a bike I can go way farther. So, I had this Huffy that I rode around the neighborhood, and it gave me a lot of freedom as a kid.”

Celebrate cycling (and correctly fitted bikes) Sunday, Sept. 7, at the Buffalo Bicycle Classic!

Learn more

His first “real” bike as a recreational and then competitive cyclist was a mountain bike, which he rode while figuring out what to do during the several years he lived in Breckenridge between high school and college. “I moved to Breckenridge and just got hooked on endurance sports, especially mountain biking, and I said, ‘I need to go study the science of this.’”

He came to CU ��ý�� and joined the cycling team, eventually realizing that he didn’t want to pursue professional cycling and that the science of riding held a lot more fascination for him. Plus, he brought to the performance lab and insiders knowledge of the problems cyclists could have.

“One of the studies that we did with Rodger (Kram) was measuring aerodynamic drag on bikes, and I saw how big of an opportunity fit was,” Carver says. “You can have a really fast bike, and that’s good, but the human body makes up 80 to 90% of drag.

Todd Carver (left) works with a cyclist to gather data for a bike fitting. (Photo: Todd Carver)

“To this day, we still do that analysis with all of our pro riders. We take them to the velodrome, measure aerodynamics and then work with fit to try to improve it. I’d almost say that one of the biggest impacts we’ve had is helping send professional and career cycling more toward science.”

After earning his master’s degree, Carver worked at the ��ý�� Center for Sports Medicine, where he and an engineer colleague, Cliff Simms, soon realized that people were flying in from as far as Europe to get fitted for bikes. He wondered why they couldn’t get fitted in their hometowns, “and it really came down to the technology. For a bike shop to get the digital technology was too expensive and it was too hard to run—you basically would need a master’s degree in biomechanics to do it—so this engineer friend and I started to look at how we could break down those barriers.”

They began developing a motion-capture system that measures length and trigonometric relation between small LED markers placed all over the cyclist’s body and synchronized to flash at certain times, a process that happens in milliseconds. 3D cameras positioned around the rider record the data, which is immediately analyzed and used to fit riders to bikes with millimeter precision.

Affordable, portable, easy to use

With partner Franko Vatterott, Carver and Simms founded Retül in 2007 with a goal of making bike fitting more affordable, portable, easy to use and data driven.

“I say I got my MBA starting a company,” Carver says. “I knew nothing, and I learned it starting a company. One big thing we learned is you better have a darn good product, and what we felt we had was a really good product, so that made some things easier. We didn’t need to take investment initially; we were able to just bootstrap it and work off the money we were making (during development).”

They also were building a database containing everything they were learning about different types of bodies and how they fit on bikes—data they knew would be appealing to bike manufacturers. In fact, he adds, the goal was always to sell to Specialized, which had worked with doctors on ergonomic design and lacked only data from digital fitting.

Todd Carver (right) shows a cyclist data from a digital bike fitting. (Photo: Todd Carver)

They initially worked with professional riders, drawing on connections Carver had made with riders in CU ��ý�� performance labs, and marketed Retül to fitting pro teams. “Then bike shops were coming to us saying, ‘We’d like to buy one of your systems.’

“From the rider point of view, what I was hearing was, ‘Wow, that feels way better, and it’s easier for me to pedal’ or ‘That completely got rid of my injury and now I can push harder.’ The problem might not be the bike itself, it just might be the saddle or the shoe or the footbed, or it just might be that the rider needs to reposition themself on the bike. From the rider point of view, that’s powerful because they could see that bike shops weren’t always trying to sell them a new bike, but had the data to say, ‘Let’s try a new saddle.’”

‘More fun with data’

As head of human performance for Specialized, Carver continues to work with riders at all levels and in all areas of cycling.

“We work in optimizing athlete and product performance using science,” Carver says. “In addition to fitting pros and selling fit systems to retailers, we do a lot of research and development—we take that fit knowledge we have and are able to then use that for ergonomic design of saddles, shoes and hand grips.

“How hand grips are shaped, for example, affects how a rider’s hand sits, which can mean the difference between a comfortable hand and one that goes numb. So, what we do is prototype and test and gather data for better design. We do so much work in saddles, which is the hardest thing on a bike to get right, so we’re always testing with pressure mapping.”

The overarching goal, Carver says, is to solve riders’ problems, “and that’s more fun with data.”

Carver often considers whether his life’s work is science or art, and figures it lives somewhere between the two: “We use scientific tools, have all these ranges, but we can’t know everything from that. I think that’s where the art comes in. You need to work with a lot of different riders—some who just want to ride bikes down to the grocery store and don’t want to be aerodynamic or fast—and you have to be able to empathize with that as well as the more competitive side of cycling. You have to have the human side, too, and really read people, have really good interviewing skills and listening skills to know what they want to do on a bike.

"I think I can empathize because I still love to ride, and I still feel that freedom when I get on my bike.”

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For CU ��ý�� alumnus Todd Carver, what he learned in the lab as a student inspired industry-rocking innovation in developing digital bike-fitting technology.

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Top image: A cyclist receives a bicycle fitting using technology co-developed by CU alumnus Todd Carver. (Photo: Todd Carver)

Raised with pets? Your immune system remembers

Rachel Sauer — Tue, 12 Aug 2025 16:46:30 +0000

Raised with pets? Your immune system remembers Rachel Sauer Tue, 08/12/2025 - 10:46

Cody DeBos

CU ��ý�� researchers, with an international team of colleagues, find that childhood pets are linked to healthier stress responses

If you grew up in a city and without a pet, your immune system likely developed differently than that of someone who shared their childhood with a dog or cat. That difference, new research from ��ý�� Professor Christopher Lowry suggests, could influence how your body responds to stress even decades later.

In a study published in the journal Brain, Behavior, and Immunity, an international team of researchers, including Lowry and CU ��ý�� PhD student John Sterrett, found that for people raised in urban environments, having regular contact with pets early in life may protect against harmful immune responses to stress.

CU ��ý�� scientist Christopher Lowry and his research colleagues found that having regular contact with pets early in life may protect against harmful immune responses to stress.

“Being raised in a home with pets can provide protection against chronic low-grade inflammation, which we know is a risk factor for stress-related psychiatric disorders and more,” Lowry says.

The study adds to a growing body of evidence that our childhood environments can leave a lasting mark on our physical and mental health.

Our oldest friends

Lowry is a professor in the Department of Integrative Physiology at CU ��ý�� and has spent much of his career studying how the microbial world interacts with the human brain. It’s a fascination that traces back to the 1990s when he started exploring how soil microbes influence mood.

“For about 25 years, we have been interested in understanding how microbes found in our environment—in nature, soil, fermenting vegetable matter, and unpurified water—can signal from the body to the brain,” Lowry says.

Along with a research team directed by Stafford Lightman at the University of Bristol’s University Research Center for Neuroendocrinology, Lowry studied Mycobacterium vaccae NCTC 11659 (M. vaccae), a microbe commonly found in soil.

His lab found that exposure to M. vaccae in mice activated serotonin pathways in the brain and produced antidepressant-like behavioral effects.

“M. vaccae is representative of diverse microbes in nature that have the ability to promote immunoregulation and protect us from inappropriate inflammation,” Lowry explains.

The microbe soon became a model for studying what scientists now call “Old Friends”—the microorganisms humans co-evolved with and depend on for proper immune system development.

“Being raised in a home with pets can provide protection against chronic low-grade inflammation, which we know is a risk factor for stress-related psychiatric disorders and more,” says CU ��ý�� researcher Christopher Lowry. (Photo: Bonnie Kittle/Unsplash)

It’s thought that modern urban living, with its clean indoor environments and reduced contact with naturally occurring microbes, disrupts this relationship. In turn, people living in such environments have experienced a rise in chronic, stress-related disorders.

Pets as microbial messengers

In a previous study, Lowry and his colleagues showed that people raised on farms, with regular exposure to animals, exhibited lower inflammatory responses to psychological stress. But in that study, it was hard to separate the effects of rural living from contact with animals.

So, the team designed a new study to answer a more specific question.

“We designed the study to determine if having pets in the home could protect against inappropriate inflammation in individuals raised in urban settings,” Lowry says.

The team recruited healthy adult men who had been raised in cities either with or without household pets. The participants were then exposed to the Trier Social Stress Test, and measurements of their immune function and inflammation were taken both before and after completing stressful tasks like public speaking.

Compared to their pet-free peers, individuals who grew up with pets showed a more balanced immune response and better regulation of stress-reactive cells.

But what accounts for this striking result?

“Exposures to ‘Old Friends,’ which are thought to increase in homes with pets, interacts with our immune system to produce more regulatory T cells,” Lowry explains. “Without sufficient exposure to ‘Old Friends’ we have reduced capacity to produce these regulatory T cells, which leads to inappropriate or unresolved inflammation.”

In short, a four-legged friend in the house means more microbial diversity. That might be just what your immune system needs to stay in balance.

Something as simple as living with a pet could help buffer the long-term health risks of urban living, notes CU ��ý�� researcher Christopher Lowry. (Photo: Helena Jankovičová Kováčová/Pexels)

From theory to therapy

Lowry and his team’s findings are just the beginning. He is now involved in several projects exploring how they could be applied in the real world.

“We are interested in exploring if we can increase mental health outcomes by increasing exposure to ‘Old Friends,’” he says, pointing to clinical trials testing microbial supplements and high-diversity plant-based beverages, which contain diverse microbial communities.

He’s also a co-founder of a CU ��ý�� startup company Kioga, which is developing soil-derived microbiome-based nutritional supplements, food ingredients and therapeutics. Their goal is to improve mental health outcomes for anyone experiencing high levels of perceived stress, whether or not they have a diagnosed disorder.

What comes next?

Lowry also notes that more research is needed to explore if the recent findings hold true for women or people of different ages or backgrounds.

“This is an extremely important question,” Lowry says. “More work is needed to fully understand the importance of upbringing in rural versus urban lifestyles in females.”

Still, the implications are clear. Something as simple as living with a pet could help buffer the long-term health risks of urban living. Given that more people than ever today live in cities and stress-related conditions are on the rise, Lowry’s work offers a hopeful solution.

“Humans co-evolved with these microbes in nature, and our body depends on them for a normally functioning immune system,” he says.

So, the next time you’re scrubbing muddy paw prints off the floor, remember that your four-legged friend is just trying to help you stay healthier in the long run.

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CU ��ý�� scientist Christopher Lowry and research colleagues find that childhood pets are linked to healthier stress responses.

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Medical issues and neighborhood opportunity can affect infant development

Rachel Sauer — Mon, 04 Aug 2025 20:21:30 +0000

Medical issues and neighborhood opportunity can affect infant development Rachel Sauer Mon, 08/04/2025 - 14:21

Sarah Kuta

CU ��ý�� researcher Emily Yeo finds that some babies may benefit from more support and resources so they can grow up to lead long, happy and healthy lives

In an ideal world, every baby would be born perfectly healthy. Unfortunately, many newborns arrive prematurely or suffer from medical conditions that could hinder their future development.

Some of these high-risk infants live in neighborhoods with access to healthy food, low crime rates and affordable housing. Others, however, live in worse-off communities with limited access to quality education, health care, housing and jobs.

Now, new research led by CU ��ý��’s Emily Yeo explores how medical complexity and neighborhood opportunity might affect the development of high-risk infants.

Emily Yeo, a PhD student in the CU ��ý�� Department of Integrative Physiology, led research exploring how medical complexity and neighborhood opportunity might affect the development of high-risk infants.

The findings, recently published in the Journal of Pediatrics, suggest some babies may benefit from more support and resources so they can grow up to lead long, happy and healthy lives.

“What the study highlights is that there’s sort of a double burden on medically complex infants living in lower-opportunity neighborhoods,” says Yeo, a doctoral student in the Department of Integrative Physiology. “There needs to be a lot more research into how we can better support these infants, especially within the first couple of years of their lives, which are critical for development and when small interventions could have a huge, life-long impact.”

Studying high-risk infants in California

Public health professionals have long understood that social, environmental and economic factors affect human health and development. Everything from a person’s income and education levels to the purity of the air they breathe and their access to grocery stores can play a role in their well-being.

Against this backdrop, scientists wanted to understand whether there was a relationship between the complexity of infants’ medical conditions, their neighborhood opportunity and their developmental progress.

“To fully understand the developmental challenges these infants face, it is essential to consider how their medical conditions interact with the social and environmental contexts of their upbringing,” says Yeo.

The team studied 440 infants born in Southern California between 2014 and 2023. Doctors had deemed these babies “high-risk” because they were born prematurely, had very low birth weights or suffered from conditions that required treatment in a neonatal intensive care unit.

By reviewing the infants’ medical records, scientists were able to categorize them based on the seriousness of their situation. Infants with the highest level of medical complexity, for instance, had conditions like permanent brain damage or chronic respiratory issues. Those with the lowest level of medical complexity, meanwhile, had more easily treatable conditions, like acute lung or eye infections.

Researchers also assessed each child’s neighborhood opportunity level, based on their home address. For this, they turned to the Child Opportunity Index, a pre-existing, composite index that analyzes education, health, social and economic data from every census tract in the United States.

Some neighborhoods earn high scores, because the children who live there have access to quality schools, clean air, health care, playgrounds and other conditions that will help them grow up healthy and become thriving adults. Other neighborhoods, however, offer very few or none of these resources. Black, Hispanic and Native American children are more likely to live in very low-opportunity neighborhoods compared to their White peers.

For each child, researchers also collected developmental scores from standard tests conducted when they were between the ages of 4 months and 36 months old. The scores came from the Bayley Scales of Infant and Toddler Development, which doctors consider the “gold standard” for evaluating infant cognitive, motor and language skills, the researchers write in the paper.

CU ��ý�� researcher Emily Yeo found that childhood development is affected by both medical and social factors, which aligns with what pediatricians see in daily practice. (Photo: Emily May/Unsplash)

When the scientists analyzed all of the data they had gathered, some clear patterns began to emerge. Developmental scores got worse as medical complexity increased, meaning that infants with more severe and complicated health conditions had lower cognitive, motor and language scores. These finding are consistent with previous studies, says Yeo, which have found that infants with fewer medical complications are also likely to face fewer challenges achieving growth milestones.

The study also found that medical complexity had a more significant effect on developmental outcomes than gestational age, or how early a baby was born. This is an important takeaway for pediatricians, who have long used gestational age to predict potential developmental delays or issues, says Yeo.

“Gestational age might be useful for infants who are not medically complex, but if you’re looking specifically at those infants, we need a more granular tool,” she says. “With this group of infants, we saw that gestational age didn’t really play a huge role in deciphering differences in development, whereas their degree of medical complexity did.”

The researchers also found a correlation between lower neighborhood opportunity scores and decreased language scores, but not cognitive and motor scores. The reasons for this discrepancy are not clear. But, overall, this finding indicates that where an infant lives does seem to play a role in their development.

Importantly, the study also ruled out differences in development based on race and ethnicity alone. Black and Hispanic babies did have lower developmental scores than White babies, but the findings indicate those disparities resulted from differences in the infants’ socio-demographic and medical factors.

“The differences do not come from race and ethnicity itself—they come from other influential factors that tend to be worse in those groups,” says Yeo, adding that this finding aligns with the general shift from race-based to race-conscious medicine.

More social supports for development

Together, the study results align with what pediatricians see in real life—that childhood development is affected by both medical and social factors. The research also highlights the importance of early intervention programs and policies designed to help children succeed.

“It’s one more indication of how, if we really want to move the needle and improve the outcomes of these babies that are born with medical risk factors, we need to put as many social supports in place as we can to support their development,” says study senior author Christine Mirzaian, a pediatrician at Children’s Hospital Los Angeles and an associate professor of clinical pediatrics in the Keck School of Medicine at the University of Southern California.

“It’s not just the child’s medical diagnosis that is going to impact their development—it’s also the neighborhood the child is brought up in, how much medical care their family is able to afford and other barriers.”

The study did not explore the possible mechanisms at play—that is, why medical complexity and neighborhood opportunity seem to be linked with development. But the researchers have a few theories.

For one, children with very serious health issues often need to use medical equipment that helps them breathe and eat—like feeding tubes in their stomachs or oxygen tubes in their noses. From a purely physical standpoint, these devices may make it difficult for infants to do “all the basic things babies do,” Mirzaian says, like rolling around or pulling themselves up to a standing position.

Another possible explanation is that a child’s appointments and treatments may leave little time for activities that promote development, like reading and playing with toys, Mirzaian adds.

Families living in neighborhoods with low opportunity scores, meanwhile, may be grappling with poverty—and having a baby with a serious medical condition likely only adds to their stress. Through no fault of their own, caregivers may need to focus more on basic needs—like how they’re going to pay next month’s rent or put food on the table—and less on their child’s development, says Mirzaian.

‘Medical Data Alone Does Not Tell the Whole Story’

Looking ahead, the co-authors hope other researchers will repeat and replicate the study, perhaps in other geographic locations or with slightly different populations. Future work might also involve following the same children as they grow up, to see whether and how their developmental outcomes change over time.

For now, though, the study is a good first step toward understanding the link between medical complexity, neighborhood opportunity and development. Zooming out, the findings also reinforce the idea that “medical data alone does not tell the whole story,” says Yeo.

“It’s important for researchers to consider social explanations to formulate a holistic picture of infant development,” she adds. “It’s not just the child’s medical diagnosis that is going to impact their development—it’s also the neighborhood the child is brought up in, how much medical care their family is able to afford and other barriers.”

In addition to Emily Yeo, Nathan Young, Joseph Cleveland, Tamara Simon, Douglas Vanderbilt, Juan Espinoza, Christine Mirzaian and Tanya Alderete contributed to this research. Alderete was previously a faculty member in the CU ��ý�� Department of Integrative Physiology.

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CU ��ý�� researcher Emily Yeo finds that some babies may benefit from more support and resources so they can grow up to lead long, happy and healthy lives.

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Top photo: Philip Mroz/Unsplash

Cycling tradition meets biomechanics at CU

Rachel Sauer — Thu, 31 Jul 2025 18:47:46 +0000

Cycling tradition meets biomechanics at CU Rachel Sauer Thu, 07/31/2025 - 12:47

Cody DeBos

In time for Buffalo Bicycle Classic, CU ��ý�� researchers challenge cycling norms that stiff cycling-shoe soles are essential for efficient riding

Years ago, Rodger Kram, a biomechanics researcher and now ��ý�� associate professor emeritus of integrative physiology, offered a student in his lab a challenge.

Asher Straw, a sophomore at the time and an avid cyclist, was convinced that stiff, carbon fiber soles were essential for serious riders because they made for more efficient pedaling. Kram, with a twinkle in his eye, disagreed.

“I provocatively said that I didn’t think they made any difference,” Kram recalls. “I figured even very flexible running shoes would be just as efficient as carbon fiber cycling shoes when riding at a steady pace and moderate intensity.”

Rodger Kram is a biomechanics researcher and CU ��ý�� associate professor emeritus of integrative physiology.

Straw was determined to prove his professor wrong. So, the two set out on a small but illuminating study and found that ultra-stiff shoes didn’t offer improved efficiency during moderate cycling.

But that was just the beginning.

Kram and his students have since spent nearly a decade exploring a deceptively simple question: How stiff does a cycling shoe really need to be?

The answer, it turns out, may surprise even the most gear-obsessed riders.

The stiffness myth

Carbon fiber shoes have been marketed as the gold standard for years, and riders have adopted the message. These shoes are sleek and featherlight, and their unyielding soles allegedly transfer more power from leg to pedal.

Kram’s research team, including then-graduate student Tripp Hurt, conducted a study to test the limits of this belief. They equipped trained cyclists with a set of three identical shoes, each fitted with a unique sole material of varying stiffness. The cyclists were then asked to sprint as hard as possible up a 50-meter stretch of road in each pair.

After multiple experiments, the researchers had their answer.

“There was a breakpoint,” Kram says. “Below a certain stiffness, sprint performance does trail off.”

But not by much. Going from nylon soles (a very stiff reference) to a medium-stiff TPU (thermoplastic polyurethane) sole caused only a 3.1% drop in maximal one-second power output. The more flexible, soft TPU sole yielded a further power-output decrease of just 2.4%. At those levels, most cyclists wouldn’t notice the difference.

“The $150 shoes were just as good as the $450 shoes,” Kram says.

Comfort over carbon

“For most of us, like riders in the Buffalo Bicycle Classic, there are far more important qualities in a shoe beyond sprint performance. Are they comfortable would be number one. Do they fit your foot?” Kram asks, adding that when picking out new shoes, “sole stiffness should be way down your list.”

“For most of us, like riders in the Buffalo Bicycle Classic, there are far more important qualities in a shoe beyond sprint performance. Are they comfortable would be number one. Do they fit your foot?” asks researcher Rodger Kram. (Photo: Wikimedia Commons)

It’s a refreshing perspective in a world where the latest (and often most expensive) iterations are always advertised the loudest. Stiff soles may seem impressive in an ad, but they aren’t always practical, Kram says. They can even be a hazard.

“Social riders often stop for a snack or coffee, and it’s easy to fall when trying to walk in carbon fiber soles on the tile floor of a café,” Kram says.

There’s also a growing awareness of carbon fiber’s environmental toll. Making carbon fiber is energy intensive and expensive, and the end product is nearly impossible to recycle. Though the sole of a cycling shoe isn’t world-ending, the cumulative effect of our consumption habits adds up.

If riders are sacrificing comfort, affordability and sustainability for just a few watts of power they may never use, Kram wonders, what’s the point?

Lab to innovation

That question stuck with Tripp Hurt, the aforementioned CU ��ý�� graduate. Inspired by the science, he found Brevay, a shoe startup based in Seattle.

“I had my ‘lightbulb’ moment after a night out with friends,” Hurt says. “I started to think about my biomechanics research and how it was relevant to the overall cycling market. We see these results, but nothing has changed about the way cycling companies were building their product.”

So, Hurt decided to build a new kind of shoe. Brevay’s first model, the Road One, will be a high-performance road cycling shoe made from sustainable materials.

“Sustainability and performance are the north star for Brevay. We’re the first brand developing a sustainable cycling shoe, so the market is unproven if this is a category that cyclists are interested in. But we’re building it anyway,” Hurt says.

This year, Rodger Kram will work at the Buffalo Bicycle Classic aid station near his home in Ward, handing out water and snacks to the riders. Though he’s retired from teaching, he nevertheless considers it important to help make CU Bulder affordable for the next generation of curious students.

That means sourcing bio-based materials, investing in an alternative supply chain and pricing the shoes competitively with the high-end carbon-fiber models they aim to replace.

Challenging assumptions

For Kram, the research is about more than shoes.

“We love challenging conventional wisdom,” he says, “and cycling is a sport fraught with tradition.”

That spirit of inquiry is part of what makes CU ��ý��’s research culture special, he adds. The study, and its illuminating results, started with a student’s curiosity and a professor’s willingness to be proven wrong.

“It represented a major shift in my career trajectory,” Hurt says of his time in Kram’s lab. “I felt more at home working on running and cycling biomechanics.”

As elite athletes continue to chase fractions of a second, Kram and Hurt hope their work encourages others to rethink what performance really means.

For many, like riders tackling ��ý�� Canyon to fundraise for scholarships in the Buffalo Bicycle Classic, choosing the right shoe shouldn’t be about speed, Kram says, but about enjoying the ride, staying comfortable and being mindful of the environment.

In the end, as Kram puts it, “there are far more important qualities in a cycling shoe than sprint performance.”

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In time for Buffalo Bicycle Classic, CU ��ý�� researchers challenge cycling norms that stiff cycling-shoe soles are essential for efficient riding.

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'Your love will be your legacy'

Rachel Sauer — Wed, 23 Jul 2025 13:30:00 +0000

'Your love will be your legacy' Rachel Sauer Wed, 07/23/2025 - 07:30

Sarah Kuta

Losing her father to pancreatic cancer inspired CU ��ý�� undergraduate Giovanna Ruffolo to raise money for cancer research and pursue a career in medicine

Giovanna Ruffolo was a senior in high school when her dad died of pancreatic cancer.

While other students were looking forward to prom and graduation, Ruffolo was navigating a web of tangled emotions—shock, disbelief, sadness, anger, uncertainty.

“Losing a parent is probably the most intense pain someone can feel in their entire life,” she says. “It’s a terrible, terrible pain.”

Giovanna Ruffolo (second from right) with her brothers Leo (left, a 2024 CU ��ý�� graduate) and Joey (second from left, a CU Denver student) and their mom, Rosanna. (Photo: Giovanna Ruffolo)

Mostly, though, she just felt numb. Heading off to college so soon after her father’s death was the last thing she wanted to do. But she knew education was important to her dad, so she pushed through the pain and enrolled at CU ��ý��.

Now a senior studying integrative physiology and psychology, Ruffolo is preparing for a career in medicine so that, someday, she can help support families just like hers. She hopes to work in pediatric oncology, providing compassionate care to children who are fighting cancer.

As a Buff, Ruffolo is also honoring her father’s legacy by raising money and awareness for cancer prevention research, an initiative she started just after her father got his diagnosis.

“I just want people to know they have a support system and a network that hates cancer as much as they do—that they’re not alone,” she says.

Helping others

Life was rolling along for the Ruffolo family when they got the news that would change their lives forever. In 2017, their beloved patriarch, John Ruffolo, was diagnosed with pancreatic cancer, a disease that is often fatal.

“It hit us like a bus,” says Ruffolo.

Pancreatic cancer is the third-leading cause of cancer-related deaths in the United States, according to the National Institutes of Health. Between 2015 and 2021, the five-year survival rate was just 13.3 percent—much lower than other types of cancer. In 2025, the American Cancer Society estimates 67,440 people will be diagnosed with pancreatic cancer and 51,980 people will die from the disease.

“It’s the cancer that really gives cancer its bad name,” Ruffolo says.

Prospect Ridge Academy High School Students participate in a cancer fundraiser organized by Giovanna Ruffolo in 2019. (Photo: Giovanna Ruffolo)

Ruffolo was just 14 at the time, but she felt compelled to take action. As a sophomore at Prospect Ridge Academy High School, she created TeamRuffolo, a student-led initiative to raise money and awareness for cancer research.

In November 2018, her school hosted a “Purple Out”—a one-day event in which students were encouraged to wear purple to show their support for the cancer community and donate whatever they could toward prevention research. Students, teachers and administrators raised more than $1,000 for the American Cancer Society that day, and Ruffolo went home feeling inspired and hopeful.

She organized similar fundraisers at her high school in 2019 and 2020 (though the initiative had to go virtual because of the COVID-19 pandemic).

“It was such a wonderful feeling,” she says. “A lot of these people didn’t even know my dad, but they were still so supportive. Seeing people come together not only for him, but just to say, ‘You’re not alone,’ was tremendous for all of us.”

Balancing act

Meanwhile, despite undergoing various treatments and surgeries, her father’s cancer continued to progress. Four years after his diagnosis, he succumbed to the disease in January 2021 at the University of Colorado Anschutz Medical Center.

Ruffolo was utterly devastated, but she knew she had to finish high school and get a college degree for her dad. And, wherever she ended up next, she wanted to continue her awareness-raising and fundraising events to support other cancer patients and their families.

CU ��ý�� participants run in the Stronger Together Annual 5K at CU in 2024, the event's most successful year. (Photo: Giovanna Ruffolo)

At CU ��ý��, Ruffolo has thrown herself into her studies, with an ultimate goal of working in the medical field. From her father’s experience, Ruffolo learned first-hand that cancer affects more than just the body—it also influences a patient’s mind, spirit and emotions. With that in mind, she’s majoring in integrative physiology and psychology to create her own pre-health pathway.

“My father had trouble grasping being diagnosed with a terminal disease, as anyone rightfully would,” she says. “I want to understand people’s behaviors and thoughts better, so that when someone is going through a hardship, I can better support them.”

To further build her skill set, Ruffolo also completed CU’s emergency medical technician (EMT) program, an online, non-credit specialization that prepares students for national registry testing. She has also worked as a research assistant at CU ��ý�� and Children's Hospital Colorado.

In addition, Ruffolo has taken on a leadership role with the CU ��ý�� chapter of the American Medical Student Association, spending three years on the executive board before being elected president for the 2025-26 school year. Through the student group, Ruffolo has carried on her TeamRuffolo efforts—now called Stronger Together—by organizing 5-kilometer run/walk events to raise money for the American Cancer Society.

She is also a journey leader with New Student & Family Programs, where she helps incoming freshmen navigate the CU ��ý�� experience. Balancing her studies with her extracurricular activities—while also supporting her family and honoring her father’s legacy—has been challenging. But, for Ruffolo, it all comes back to staying true to herself.

“Pretty much my tippy-top value is helping others,” she says.

In class, Ruffolo has never been afraid to ask questions and speak up—even when that means talking about her father’s death in a large lecture hall full of hundreds of students. Jennifer Stratford, a CU ��ý�� teaching associate professor of psychology and neuroscience, says Ruffolo’s willingness to be vulnerable has opened the door for other students to share their experiences.

John Ruffolo died from pancreatic cancer in 2021. (Photo: Giovanna Ruffolo)

“She just kind of became an ambassador and a face for students who have lost parents,” says Stratford. “I’ve had a lot of feedback from students about how much they appreciated her bravery and how much they identified with some of the struggles she’d been through. It’s a once-in-a-decade or once-in-a-lifetime experience to see a single student have an impact on so many of her classmates.”

‘Your love will be your legacy’

Since high school, Ruffolo estimates she’s helped raise more than $20,000 for the American Cancer Society. And she’s not done yet. She hopes the CU ��ý�� AMSA chapter will continue organizing the 5K run/walk fundraisers, and that she’ll be able to host similar events during the next phase of her educational journey.

For now, Ruffolo is focused on finishing up her studies so she can graduate in the spring of 2026. From there, she hopes to continue her education in the medical field, likely as a doctor or physician assistant specializing in pediatric oncology.

“I really want to serve that specific community,” she says. “You’re treating little people who have lots of emotions and a little body. They get very scared easily. You really have to be empathetic and treat them and their families with kindness. I love the idea of sitting down with people, holding their hands, talking to them—not just giving them a death sentence, walking out the door and saying, ‘Best of luck.’”

That approach stems directly from her father’s experiences. As he neared the end of his life, Ruffolo remembers him breaking down and talking about how scared he was. She hopes to be the kind of practitioner who will help people like her dad move forward through their pain and fear, while also treating their underlying illness.

“Your love will be your legacy,” she says. “In a world where there’s no cure for cancer, investing your time in others is the only way you can live forever. And loving other people—giving them kindness and empathy—is one of the best ways to help fight any disease.”

Losing her father to pancreatic cancer inspired CU ��ý�� undergraduate Giovanna Ruffolo to raise money for cancer research and pursue a career in medicine.

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Top image: Giovanna Ruffolo (right) and her late father, John, representing Colorado cancer patients and survivors at Mile High Stadium at an event sponsored by the American Cancer Society in 2019. (Photo: Giovanna Ruffolo)

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